Project data

Project Name: The treatment of depression. Differential efficacy of different therapeutic components applied through the Internet

Reference: PSI2014-60980-JIN

Concession year: 2015

Financing Program: I+D+I projects for junior researchers

Funding Entity: Ministry of Economy and Competitiveness

Coordinator: Adriana Mira

Brief description of the Project:

Depression is one of the most important worldwide health problem and it generate significant costs in term of economic, personal, and social investments. If depression is not treated properly, it could become chronic and could interferes significantly in all areas of functioning. Therefore, one of the most important challenge is to develop new treatments in order to maximize the therapeutic efficiency and effectiveness. The Information and Communication Technologies (ICTs) have proven to be efficacious instruments for those who are in need. Several international research groups have launched self-applied treatment programs through Internet to address the problem.
The results found so far are consistency and encouraging, and they showed that the internet intervention could be an efficacious method. However, the psychological interventions are characterized by various therapeutic components and it is important to delineate each proper contribution. Moreover, the majority of the intervention are based in the regulation of negative affect and they do not take into account the regulation of the positive one. For this, the main objective of the present study is to analyze the components of a general protocol to determine the differential efficacy of three short self-applied interventions for moderate-level of depression through internet: (1) a protocol of different therapeutic components including psychoeducation, cognitive restructuring, behavioral activation, positive psychology, and relapse prevention; (2) a protocol based on behavioral activation without the positive psychology component; and (3) a protocol based on positive psychology without the behavioral activation. The participants are randomly allocated to one of the conditions.

Our participation consists of: Coordination, development, and execution of the project.


Associated publications:

Botella, C., Mira, A., Herrero, R., García-Palacios, A., & Baños, R. (2015). Un programa de intervención autoaplicado a través de Internet para el tratamiento de la depresión: Sonreír es divertido. Aloma, 33(2), 39-48. ISSN: 1138-3194.

Botella, C., Mira, A., Moragrega, I., García-Palacios, A., Bretón-López, J., Castilla, D., … y Baños, R.M (2016). An Internet-based program for depression using activity and physiological sensors: efficacy, expectations, satisfaction, and ease of use. Neuropsychiatric disease and treatment, 12, 393.

Mira, A., Bretón-López, J., García-Palacios, A., Quero, S., Baños, R. M. y Botella, C. (2017). An Internet-based program for depressive symptoms using human and automated support: a randomized controlled trial. Neuropsychiatric disease and treatment, 13, 987. doi: 10.2147/NDT.S130994

Mira, A., Bretón-López, J., Enrique, A., Castilla, D., Garcia-Palacios, A., Baños, R. M., & Botella, C. (2018). Exploring the incorporation of a positive psychology component in a cognitive behavioral Internet-based program for depressive symptoms. Results throughout the intervention process. Frontiers in Psychology, 9, 2360. doi: 10.3389/fpsyg.2018.02360

Karyotaki, E., Kleiboer, A., Smit, F., Turner, D. T., Mira, A., Andersson, G., … y Christensen, H. (2015). Predictors of treatment dropout in self-guided web-based interventions for depression: an ‘individual patient data’meta-analysis. Psychological medicine, 45(13), 2717-2726. DOI:

Karyotaki, E., Riper, H., Twisk, J., Hoogendoorn, A., Kleiboer, A., Mira, A., … y Andersson, G. (2017). Efficacy of self-guided internet-based cognitive behavioral therapy in the treatment of depressive symptoms: a meta-analysis of individual participant data. JAMA psychiatry, 74(4), 351-359. doi:10.1001/jamapsychiatry.2017.0044

Karyotaki, E., Kemmeren, L., Riper, H., Twisk, J., Hoogendoorn, A., Kleiboer, A., … y Littlewood, E. (2018). Is self-guided internet-based cognitive behavioural therapy (iCBT) harmful? An individual participant data meta-analysis. Psychological medicine, 48(15), 2456-2466. DOI: 10.1017/S0033291718000648

Mira, A., Soler, C., Alda, M., Baños, R. M., Castilla, D., Castro, A., … y Mayoral, F. (2019). Exploring the relationship between the acceptability of an Internet-based intervention for depression in primary care and clinical outcomes: Secondary Analysis of a Randomized Controlled Trial. Frontiers in psychiatry, 10, 325.  doi: 10.3389/fpsyt.2019.00325

Mira, A., Díaz-García, A., Castilla, D., Campos, D., Romero, S., Bretón-López, J., … & Botella, C. (2019). Protocol for a randomized controlled dismantling study of an internet-based intervention for depressive symptoms: exploring the contribution of behavioral activation and positive psychotherapy strategies. BMC psychiatry, 19(1), 133.